Nuclear transfer and cell transplantation: Making more with less

I-12: Nuclear Reprogramming in Bovin Somatic Cell Nuclear Transfer

Somatic cell nuclear transfer (SCNT or cloning) returns a differentiated cell to a totipotent status; a process termed nuclear reprogramming. Reproductive cloning has potential applications in both agriculture and biomedicine, but is limited by low efficiency. To understand the deficiencies of nuclear reprogramming, our research has focused on both candidate genes and global gene expression pat...

Making Less Do More at NASA.

William T. Golden Treasurer Richard S. Nicholson Executive Officer John Abelson Frederick W. Alt Don L. Anderson Stephen J. Benkovic David E. Bloom Floyd E. Bloom Henry R. Bourne James J. Bull Kathryn Calame C. Thomas Caskey Dennis W. Choi John M. Coffin Bruce F. Eldridge Paul T. Englund Richard G. Fairbanks Douglas T. Fearon Harry A. Fozzard Victor R. Fuchs Theodore H. Geballe Margaret J. Gell...

Naive theory and transfer of learning: when less is more and more is less.

In this research, we examine how young children perform induction in the domain of biology. According to the essentialist view, even young children have a priori knowledge that some predictors of biological properties are central, whereas others are peripheral. According to the flexible-learning view, the roles of predictors are not fixed, and young children flexibly learn the predictive value ...

More with less Xist.

S ince the birth of Dolly, the first mammal produced from somatic cell nuclear transfer (SCNT), little progress has been made in the efficiency of cloning. Overall, about 0.5–2% of the embryos reconstructed by SCNT develop to term after transfer of reconstructed embryos to recipient females. In PNAS, Matoba et al. (1) report significant improvement in cloning efficiency by manipulation of the l...

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